Our quest is to bridge the gap between quantitative physical models and biological observations in order to identify and resolve inconsistencies in our current understanding of life at the molecular level.
Mar 14 - 2023
The small, the fast, and Shadowfax
Elflab proudly presents Shadowfax, a new type of microscopy for tracking single molecules at high speed inside living cells.
Jan 04 - 2023
Perseverent bacteria challenge antibiotics
Bacterial perseverance is a new phenomenon that helps explain how bacteria adapt to survive antibiotic treatments. We have studied how individual bacteria react when exposed to different antibiotics. The result underlines the importance of adhering strictly to antibiotic prescriptions.
Dec 07 - 2022
Happy holidays from the Elf lab! May your new year be merry and bright and may all your experiments turn out right. Sparkles and joy from the lab Christmas tree. Look inside to see who won the Christmas tree decoration competition!
Dec 02 - 2022
On the 2nd of December, the Elf and Johansson labs hosted their yearly Christmas event, BiophysXmas. Celebrating the return to in-person meetings, we gathered in the beautiful UU main building. Still, having speakers online makes the threshold lower for invited speakers, and we had the pleasure of listning to seminars from Ethan Garner and Stefan Upphoff on link.
Nov 23 - 2022
Structural flexibility explains efficient search process
With our coarse-grained molecular model of different conformation of the lac repressor, we demonstrate how disordered regions assist both rapid exploration of the DNA and recognition of the specific site. This conformational agility explains how DNA-targeting proteins can be both fast and accurate.
Oct 20 - 2022
The right drug for the right bug
We have developed a method to identify harmful bacteria and suggest an effective antibiotic treatment within hours of sampling the patient. If this type of method is made available in the clinic, patients with complex bacterial infections would be all but guaranteed an effective treatment, and physicians could make better use of the last-resort drugs, in the long run slowing the progression of resistance development.
Aug 20 - 2022
Kick-off fall 2022 in Öregrund
The Elf group kicks off the fall together with the Johansson and Jones labs in the beautiful Öregrund archipelago. This time the focus was on our brilliant staff scientists.
Jul 06 - 2022
Loremaster elected EMBO
The European Molecular Biology Organisation, not the bounty hunter, sorry...
Jan 27 - 2022
Binding long or often - the secret of fast TF search
In a study that we recently published in Science, we show how DNA-binding proteins can slide on the DNA sequence in search of their targets without getting held up unnecessarily on unspecific DNA. The result explains how LacI and other transcription factors can be both accurate and fast when turning on and off their target genes.