Have you ever wondered how regulatory proteins can find their targets in the genome? Making it fast to the correct location can mean the difference between life and death in the competition for nutrients (LacI) or in the war against phages (Cas9). These two proteins have evolved different technique to speed up the search process. In this movie we get to follow the transcription factor LacI and the gene snipper Cas9 in their search for the correct nucleotide sequence. The movie was made by Visual Science.