Recruitments

We always welcome CVs from qualified candidates with an interesting project idea within our scope of research. We are particularöy looking for people interested in:

Chromosome structure

The structure-function relationship of the chromosome is not well understood in any organism. Even for E. coli, it is unknown whether the spatial positions of different loci are important for gene expression or if the structure mainly ensures faithful replication and segregation of the genetic material.

We investigate this question by combining learning-based image analysis and spatiotemporal modeling to integrate data from innovative large-scale single-cell experiments into a 4-dimensional model of the bacterial chromosome.

Antibiotic susceptibility diagnostics

Antibiotic drugs save millions of lives every year, but this cornerstone of modern medicine is threatened by the emergence of drug-resistant pathogens. Already today, antimicrobial resistance (AMR) has significant costs for both health systems and national economies at all income levels; the spread of resistant pathogens does not recognize country borders.

We develop fast diagnostics for antibiotic susceptibility testing based on new techniques to capture and image bacteria in microfluidic chips. Knowing the susceptibility profile of a pathogen is important to mitigate patient mortality and morbidity, but also to prevent misuse of antibiotics which further aggravates the AMR problem. Currently, we focus our efforts on Sepsis and Tuberculosis, two of the most lethal infectious diseases in the world today.