In a recent article in Communications Biology, we describe a new way to investigate dynamic behaviors in large libraries of genetically modified bacteria.

In a recent study, we tested a new method for TB drug susceptibility testing and concluded that in the model organism M. bovis BCG, test results can be obtained within 12 hours. This is good news for TB patients since it could shorten the susceptibility testing turnaround time by around two weeks.

Konrad Gras defends his thesis entiteled The Dynamic Structure of the Escherichia coli Chromosome

Traditional 2D imaging methods can capture movement across a flat plane but miss details along the depth-axis. In this project, we train a neural network to locate fluorescent markers in 3D by simulating training data based on experimental background models. To test the approach, we track chromosomal loci throughout the E. coli cell cycle and find interesting loci-specific patterns in the yz-plane.

The Elf and Jones labs spent four days on beautiful Fårö. Elf lab alumni Emil Marklund, Petter (Hammar) Knagge, and Cia Unoson spoke about different career paths in science, and we enjoyed Zoom lectures on exciting new science from around the globe. Thank you also to Nazir Ismail, who gave us a thorough introduction to Tuberculosis - disease and diagnostics, and to the Öhmans for hosting us at their vacation home!

The bacterial replisome has the important task of copying genetic information, securing the species' survival. But how the replisome executes the process is debated. Does the complex follow the DNA (like a baby dragon running on spaghetti), or does the dragon remain stationary, slurping up the genetic strands as the copying process proceeds? A new study from the Elf lab provides the answer to this question.

From three days to 45 minutes – that's a huge improvement when you're a patient waiting for the correct treatment. A technique making it possible to test the antibiotic susceptibility of a bacterial infection in less than an hour has now been awarded the prestigious £8 million Longitude Prize in AMR. The quick test was developed by the company Sysmex Astrego, based on research in the Elflab.

In this book, two dozen eminent doctors, including Prof. Johan Elf, recount their experiences fighting AMR, illuminating the daunting daily realities that individuals and healthcare professionals face worldwide.

Praneeth Karempudi defends his thesis entiteled Microfluidics and AI for single-cell microbiology.

Malin Lüking defends her thesis entiteled Molecular Metamorphosis in Transcriptional Regulation.