Nov 11 - 2013
Lac sliding in E. Coli continued: Deeper into the mechanism
We have previously shown that the lac repressor slides along the DNA to speed up the search for its specific binding site. By combining micro- and macroscopic computational models, we have now been able to investigate the details of the sliding mechanism on the atomic scale.
May 14 - 2013
New insights in TF kinetics
In a recent publication, we show that there exist an optimal TF binding strength, where the time the binding site is free is not dependent on TF concentration.
Feb 24 - 2013
It's not that simple!
A new method for direct measurement of transcription factor dissociation makes it possible to exclude a simple operator occupancy model for gene regulation.
Oct 11 - 2012
New Release: MesoRD-1.1
Bugfixing and updated code for the microscopically treated bi-molecular reactions.
Jun 21 - 2012
LacI sliding in E. coli
Petter's paper 'The lac Repressor Displays Facilitated Diffusion in Living Cells' is published in Science