We have developed a method to identify harmful bacteria and suggest an effective antibiotic treatment within hours of sampling the patient. If this type of method is made available in the clinic, patients with complex bacterial infections would be all but guaranteed an effective treatment, and physicians could make better use of the last-resort drugs, in the long run slowing the progression of resistance development.

The Elf group kicks off the fall together with the Johansson and Jones labs in the beautiful Öregrund archipelago. This time the focus was on our brilliant staff scientists.

The European Molecular Biology Organisation, not the bounty hunter, sorry...

In a study that we recently published in Science, we show how DNA-binding proteins can slide on the DNA sequence in search of their targets without getting held up unnecessarily on unspecific DNA. The result explains how LacI and other transcription factors can be both accurate and fast when turning on and off their target genes.

Let's bring the year 2021 to a happy conclusion. Send some love to your friends and family and make some time for well-deserved rest; maybe it's time to brush up on your knitting...

In a recent publication in Nature, we show how RecA filaments reduce the dimensionality of homologous recombination search from 3D to 2D, considerably speeding up the DNA repair process.

The MSB program learns about open science and enjoys the autumn in the orchard of Krusenberg

Arvid Gynnå defends his thesis entiteled Bacterial DNA repair and molecular search.

In a recent publication in Nature, we show how transcription factors are trading accuracy for speed when scanning the DNA. Although the transcription factor will frequently miss the target site, it will revisit the sequence enough times to ensure rapid binding

Antibiotic resistance is a global health problem caused by the use and misuse of these drugs. The problem is exacerbated by the lack of new antibiotics and rapid diagnostic methods to identify the bacterial agents and their antibiotic susceptibility. In this project, we will develop diagnostic tools that will prolong the lifespan of existing and future antibiotics by allowing us to use them rationally—i.e. only for bacterial infections and when the bacterium is susceptible.